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Schematic of the construction of biointerface for the recognition of bioanalyte

For any analytical approach detecting a biological substance, an essential step is to build a biointerface on the surface of the substrate (e.g. chip or particles) for efficient capture of bioanalyte as well as preventing non-specific adsorption from other interference substances. An effective biointerface is important for increasing the analytical performance and allow a direct analysis in crude biofluids (such as blood and urine) without pre-purification. The construction of a biointerface involves a proper surface chemistry for the anchoring of a suitable bioreceptor for the recognition of the analyte, as well as the coating of the antifouling layer (for preventing the non-specific adsorption). 

We are currently working on the following topics to develop biointerface for our analytical technologies:​

  1. Use surface plasmon resonance for the monitoring of biointeraction

  2. Develop novel surface coating for increasing the coupling efficiency of surface chemistry

  3. Explore novel bioreceptors for the binding of analyte. 

Selected publication

  1. Zhand S., Xiao K., Bazaz S. R., Zhu Y., Bordhan P., Jin D., Warkiani M. E., Improving capture efficiency of human cancer cell derived exosomes with nanostructured metal organic framework functionalized beads, Applied Materials Today 2021, 23, 100994. DOI: 10.1016/J.APMT.2021.100994

  2. Gooding J. J. and Zhu Y., ‘Modifying porous silicon with self-assembled monolayers for biomedical applications’, in Santos H. (eds), Porous Silicon for Biomedical Applications, Woodhead Publishing, pp. 81-103 (2014). DOI: 10.1533/9780857097156.1.81

  3. Yang D., Liu X., Jin Y., Zhu Y., Zeng D., Jiang X., Ma H., Electrospinning of poly (dimethylsiloxane)/poly (methyl methacrylate) nanofibrous membrane: Fabrication and application in protein microarrays, Biomacromolecules 10 (12), 3335-3340 (2009). DOI: 10.1021/BM900955P

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